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KMID : 0358819840110010017
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1984 Volume.11 No. 1 p.17 ~ p.26
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EXPERIMENTAL STUDY ON EFFECTS OF COBALT-60 RADIATION TO MICROVASCULAR ANASTOMOSIS OF RATS
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Yang Doo-Byung
Kim Tae-Youn
Chung Chun-Eun
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Abstract
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Performing clinical reconstructive microvascular surgery to previous radiated patients, the vascular changes due to previous radiation is thought to be harmful to successful microvascular anastomosis. We have performed Cobalt-60 radiation at different time intervals and different radiation doses to Sprague-Dawley rat and observed histological differences and patency rates.
The following results are obtained.
1) The vascular changes due to a Cobalt-60 radiation are mainly interstitial edema and mild inflammatory infiltration, but anatomical architecture of artery, vein, peripheral nerve and skeletal muscles are preserved.
2) In the group of microvascular anastomosis performed at immediate and 1 week interval after radiation has been shown far better results in patency rates and less histological changes than the group performed at 2 weeks and 4 weeks interval after radiation.
3) There are not any different findings in patency rates and histological changes between 500 Rads and 1,000 Rads radiation exposure doses.
4) The vascular changes due to Cobalt-60 radiation are more severe in arteries than in veins.
5) After 2weeks, the vascular changes due to Cobalt-60 radiation in arteries and veins are marked fibrosis thickening which obliterate the lumen, so we can obtain far better results in performing microvascular anastomosis before 2 weeks interval after radiation.
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KEYWORD
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